生命科学学院学术报告（一）
题 目：Towards genome-enabled conservation in freshwater fishes
主讲人：Dr. Louis Bernatchez, Professor Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Canada
主讲人简介：
Dr. Louis Bernatchez has 332 publications, among which 252 peer-reviewed papers, published, in press or submitted in 52 primary scientific journals.
Selected publications:
1. Wirth T, Bernatchez L. 2001. Genetic evidence against panmixia in the European eel. Nature. 409: 1037-1040. (129 citations ; average/year = 13 ).
2. Aarestrup K, Økland F, Hansen MM, Righton D, Gargan P, Castonguay M, Bernatchez L, Howey P, Sparholt H , Pedersen MI, McKinley RS. 2009.
First empirical results on the oceanic spawning migration of the European eel (Anguilla anguilla). Science. 325 : 1660
3. Bernatchez L, Wilson CC. 1998. Comparative phylogeography of nearctic and palearctic freshwater fishes. Molecular Ecology. 7: 431-452. (341 citations; average/year = 26 )
4. Bernatchez L, Guyomard R, Bonhomme F. 1992. DNA sequence variation of the mitochondrial control region among morphologically and geographically remote
European brown trout Salmo trutta populations. Molecular Ecology. 1: 161‑173. (234 citations ; average/year = 12)
5. Fraser DJ, Bernatchez L. 2001. Adaptive evolutionary conservation: towards a unified concept for deriving conservation units. Molecular Ecology. 10: 2741-2752. (225 citations ; average/year = 25).
6. Bernatchez l, landry c. 2003. MHC studies in non-model vertebrates: what have we learned about natural selection in 15 years? Journal of Evolutionary Biology. 16: 363-377. (202 citations; average/year = 25)
7. Bernatchez L. 2001. The evolutionary history of brown trout Salmo trutta L. inferred from combined phylogeographic, nested clade and mismatch analyses
of mitochondrial DNA variation. Evolution. 55: 351-379. (162 citations ; average/year = 22).
8. Lu G, Bernatchez L. 1999. Correlated trophic specialization and genetic divergence in sympatric lake whitefish ecotypes (Coregonus clupeaformis):
support for the ecological speciation hypothesis. Evolution. 53: 1491-1505. (133 citations; average/year = 11).
报告摘要：
Since its first formulation by Ryder (1986), the concept of “evolutionary significant unit” (ESU) has experienced several definitions diverging mainly on the
importance granted to neutral versus adaptive genetic diversity which depict distinct temporal spheres and must be assessed and interpreted differently.
The former represents the particular genetic background shaped on evolutionary time scale by neutral evolutionary forces and the latter mirrors variation of
adaptive significance resulting from the ongoing action of natural selection. While a wide range of methods have been available and efficiently used to measure
neutral variability, characterizing adaptive genetic variation is in its infancy. As this task generally requires to first identifying a small number of adaptive loci
scattered throughout the genome, genomic approaches offers the potential to accelerate substantially the discovery of such “adaptive holy grails”. I will present how the use of genomics methods, including microarray analysis of gene expression, QTL genome scans, nextgeneration sequencing and SNP genotyping helped
in finding evidence of adaptive divergence among populations of freshwater fishes. None of these new approaches are without drawbacks, so I will also discuss the
challenges and limitations of integrating their use in the context of conservation, their cost not being the least.
生命科学学院学术报告（二）
题 目：Understanding and Preventing Influenza: Genomics and Bioinformatics Perspectives
主讲人：Dr. Guoqing Lu, Associate Professor Department of Biology, University of Nebraska at Omaha, USA
主讲人简介：
Dr. Guoqing Lu has published 45 journal papers, 7 conference papers, and 4 book chapters.
Recent publications:
1.Kedwaii, A., Christman, M.C., Xu, J., Donix, R., and Lu, G. Pandemic (H1N1) 2009 Virus Revisited: an Evolutionary Retrospective. Infection, Genetics and Evolution. In press.
2.Li, S.F. J. W. Xu, Q. L. Yang, C. H. Wang, D. C. Chapman, G. Lu. Significant genetic differentiation between native and introduced silver carp (Hypophthalmichthys molitrix)
inferred from mtDNA analysis. Environmental Biology of Fishes. In press.
3.Attaluri, P. K., M.C. Christman, Z. Chen, G. Lu. 2011. SeqMaT: A sequence manipulation tool for phylogenetic analysis. Bioinformation. 5: 400-401.
4.Zhao, J., Y. Cao, · S. Li, · J. Li, · Y. Deng, and · G. Lu. 2010. Population genetic structure and evolutionary history of grass carp Ctenopharyngodon idella in the Yangtze River,
China. Environmental Biology of Fishes 90: 85-93.
5.Deng, Y., J. Zhao, G. Lu, X. Wu, and Y. Tao. 2010. Cloning, characterization and expression of the pepsinogen C from the golden mandarin fish Siniperca scherzeri
(Teleostei: Perciformes). Fisheries Science. 76: 819-826.
6.Bernatchez, L., S. Renaut, A.R. Whiteley, N. Derome, J. Jeukens, L. Landry, G. Lu, A. W. Nolte, K. Ostbye, S. M. Rogers, J. St-Cyr. 2010. On the origin of species: insights from the ecological genomics of lake whitefish. Philos Trans R Soc Lond B Biol Sci. 365:1783-800.
7.Li, S. F., Q. L. Yang, J. W. Xu, C. H. Wang, D. C. Chapman, G. Lu. 2010. Genetic diversity and variation of mitochondrial DNA in native and introduced bighead carp.
Transactions of the American Fisheries Society. 139: 937-946.
8.Ding, Y., H. Lapko, Y. Xia, A. Al-Abdallat, I. Ndamukong, M. Sadder, A. Saleh, M. Fromm, G. Lu, and Z. Avramova. 2009. The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM, and the response to drought; a view from the other end of the pathway. Plant Signaling & Behavior. 4: 1049-1058.
报告摘要：
Influenza virus causes moderate to severe seasonal epidemics and results in sporadic but often catastrophic pandemics. Due to genetic mutation and genome
reassortment, the influenza virus exhibits complicated evolutionary dynamics and thus it is very hard to predict its evolution. In this talk, I will provide a brief
introduction to influenza and the influenza virus, present the results of our recent large-scale sequence analyses on influenza virus evolution, and demonstrate a genotype prediction tool dedicated to influenza virus. With the progress and advances
in genomics and bioinformatics, I conclude, we are in a much better position in terms of influenza surveillance and vaccine development, which will eventually
lead to the prevention and control of the influenza disease.
时 间：6月14日（星期二）9:30—11:30
地 点：教学楼804教室
主办：中国科学院研究生院生命科学学院（电话: 88256348）
